This study draws on job demands-resources (JD-R) theory to explore the relationship between job demand (JD) dimensions and work burnout (WB) dimensions among Business Teacher Educators (BTEs) in public universities in South-South, Nigeria. The study was guided by four specific purposes which were translated to four research questions. The study employed a quantitative research approach, which gathered data from 142 BTEs in public universities in South-South, Nigeria using a structured questionnaire, adapted from existing psychological scales. A correlational research design was adopted to carry out the study. Two instruments were used; with one of the instruments measuring Job Demand and the other measuring Work Burn. The instruments were validated and Cronbach Alpha was used to establish the reliability index which yielded 0.843 and 0.727 respectively. The findings revealed that JD dimensions (that is, work-home conflict and excess workload) were significant positive predictors of WB dimensions (that is, emotional exhaustion, depersonalization and decreased professional accomplishment) among BTEs in public universities in South-South, Nigeria. These findings suggest that when BTEs experience JD dimensions, they will equally experience increase in WB dimensions. These findings offer some practical implications for university administrators and managers.